Total Synthesis of Brevetoxin B. 2. Completion
نویسندگان
چکیده
منابع مشابه
Total Synthesis of Brevetoxin B. 2. Second Generation Strategies and Construction of the Dioxepane Region [DEFG]
The second generation strategy for the total synthesis of brevetoxin B (1) is presented. According to this strategy, the heptacyclic [ABCDEFG] phosphonium iodide 4 and the tricyclic [IJK] aldehyde 3 were defined as the precursors for the brevetoxin B skeleton. The Yamaguchi lactonization was successfully applied for the formation of the [EFG] and [DEFG] lactones (15 7) and (29 6), respectively....
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A highly convergent, enantioselective total synthesis of brevetoxin A is reported. The development of a [X+2+X] Horner-Wadsworth-Emmons/cyclodehydration/reductive etherification convergent coupling strategy allowed a unified approach to the synthesis of two advanced tetracyclic fragments from four cyclic ether subunits. The Horner-Wittig coupling of the two tetracyclic fragments provided substr...
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ژورنال
عنوان ژورنال: Journal of the American Chemical Society
سال: 1995
ISSN: 0002-7863,1520-5126
DOI: 10.1021/ja00108a052